What is Semiconductor Sequencing? Semiconductor sequencing is the integration of microchip technology with DNA sequencing where electrical signals replace the detection of light. This sequencing method is unique because it uses complementary metal-oxide semiconductor chips associated with sequencing by synthesis chemistry; so, in this respect, it opens up opportunities to make DNA analysis quicker and … Read more
What is Trinocular Microscope? Principle of Trinocular Microscope A trinocular microscope is similar to a binocular microscope but has an additional third eyepiece for a camera. It shines an LED light on the specimen and projects it onto a computer screen through a digital camera. The trinocular microscope is essentially a binocular microscope that focuses … Read more
What is Rickettsia? Small-sized intracellular bacteria with a 0.3 to 2 µm range make up the genus Rickettsia. Rickettsia’s tiny scale made it first confused as a virus. Having DNA and RNA as their genetic material, these bacteria reproduce via binary fission within the cytoplasm of eukaryotic cells. Gram-negative rickettsia bacteria abound in the digestive … Read more
What is Urinary Tract Infection (UTI)? An illness affecting a portion of the urinary tract—that which comprises the kidneys, ureters, bladder, and urethral—is known as a urinary tract infection (UTI). Following are some salient features of urinary tract infections: Types of Urinary Tract Infection (UTI) UTIs can attack various urinary system segments, causing varied symptoms. … Read more
An electron microscope is an instrument which produces an image of a sample by means of a beam of electrons. Optical microscopes use light to form an image, electron microscopes have greater resolution, and can be used to observe objects that are too small to be seen with an optical microscope. In a large variety … Read more
What is cryo-EM? Principle of cryo EM Types of cryo EM Cryo-electron microscopy (cryo-EM) is a collection of special methods. These are broadly categorized into two types, mainly cryo-transmission electron microscopy (cryo-TEM) and cryo-scanning electron microscopy (cryo-SEM). Each has its own advantage in the analysis of biological samples in their native state, frozen by cryo-preparation. … Read more
What is Theta model of DNA Replication? The theta model of DNA replication is a mechanism for DNA replication which occurs in circular DNA molecules, in particular, those of bacteria, and also the mitochondria and chloroplasts. True to its name, this replication process creates an intermediate structure during replication that resembles the Greek letter theta … Read more
What is Codon? Molecular biologists define a codon as three nucleotides of DNA or RNA. Such is said to code for some particular amino acid, but it may also work as a signal in the course of regulation during the synthesis of protein. In brief, life proceeds generation after generation due to complex steps that … Read more
By Sourav Pan 2 revisions 13 min readby Sourav Pan
A game changer for the microscopic world is epi-fluorescence microscopy. Imagine being able to see cells as vibrant, dynamic creatures showing off their inner workings instead of just as static objects. This method, based on the principle of fluorescence, has opened up the hidden details of life at the cellular level and made the invisible … Read more
By Sourav Pan 8 revisions 23 min readby Sourav Pan
What is Telomerase? Telomerase (terminal transferase) is a ribonucleoprotein enzyme that extends telomeres, the repetitive nucleotide sequences at the ends of eukaryotic chromosomes. Telomeres function as protective caps, stopping chromosome ends from being erroneously perceived as DNA damage or from bonding with neighboring chromosomes. Most eukaryotes use telomerase to maintain their telomeres, but some organisms, … Read more
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