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Differences Between Viroids and Prions

Differences Between Viroids and Prions

In this article we will discuss about Differences Between Viroids and Prions.

Differences Between Viroids and Prions

Viroid:

Viroids are known as the smallest infectious pathogens which are made up solely of a short strand of circular, single-stranded self-replicating RNA that has no protein coating.

Prions:

Prion is an abnormal or misfolded protein that causes fatal disease in animals and humans by transmitting their misfolded shape onto normal variants of the same protein.

Differences Between Viroids and Prions

TopicViroids Prions
NatureIt is an infectious RNA particleIt is an infectious protein particle.
CompositionIt is composed of only small single stranded circular RNA.It is only composed of Protein.
Nucleic acidPresent Absent
Protein coatAbsentNot known
InactivationViroids are inactivated by ribonuclease digestion.Prions are inactivated by proteinase K and trypsin digestion.
ResistantResistant to proteinase K and trypsin digestionResistant to ribonuclease treatment.
SizeViroids are smaller than virus Smaller than viroids.
HostViroid infects only higher plants (Exception: hepatitis D virus in humans is similar to viroid)Prions infect animals causing neurological degenerative diseases
Disease NameCommon plant diseases include Potato Spindle tuber disease, Chrysanthemum stunt disease.‘Mad cow disease’ (Bovine spongiform encephalopathy) in cow and Scrapie disease in sheep and goat, Creutzfeldt-Jakob Disease (CJD), Kuru, and Gerstmann-Strausler-Sheinker syndrome in humans.

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