Capillary Electrophoresis (CE) is a type of electrophoresis technique that uses a narrow capillary to separate charged molecules (ions) based on their migration towards electrodes under the influence of an electric field. It is a high-resolution and fast method for the analysis of small molecules, DNA, and proteins. The importance of CE lies in its … Read more
What is Flow Cytometry? Definition of Flow cytometry Flow cytometry is a laser-based technology used to analyze and measure physical and chemical characteristics of cells or particles in a fluid mixture. It provides rapid and quantitative information about cell size, complexity, and fluorescence intensity, enabling various applications in research and clinical settings. Purpose of flow … Read more
In 1896, two bacteriologists, Herbert Edward Durham and Max von Gruber, independently discovered specific agglutination. In honour of the discoverers, this reaction was given the name GruberDurham reaction. Later, Gruber designated as “agglutinin” any chemical that induced an agglutination reaction (from the Latin). Fernand Widal (1862–1929) employed agglutination to diagnose typhoid disease in the same … Read more
What is Opsonization? Opsonization Definition Opsonization is the process of coating antigens with molecules called opsonins, which mark them for recognition and engulfment by immune cells, enhancing the efficiency of the immune response. Mechanism of Opsonization The mechanism was usually divided into two main pathways, antibody-mediated opsonization and complement-mediated opsonization. Both systems worked separately but … Read more
Basophils are an immunological cell type that release enzyme-containing granules during allergic responses and asthma crises. Basophil is a type of white blood cell that, together with neutrophils and eosinophils, belongs to the granulocytes category. They contain several chemicals, including histamine and heparin. As part of the body’s immune response, basophils degranulate (split open) to … Read more
Phagocytosis refers to the process in which cells consume large particles (>0.5 micrometers) and vesicle-bound membrane vesicles known as phagosomes. These vesicles are then directed to the lysosomes where they will be subjected to enzymatic degrading. Optonization of bacteria can greatly enhance phagocytosis. Although phagocytosis may occur without the attachment of an IgG or complement fragment (C3), it can be greatly enhanced by attaching a specific IgG.
What is Vaccine? Definition of Vaccines Vaccines are medical preparations that stimulate the immune system to provide protection against specific diseases by promoting the production of antibodies and immune memory. How do vaccines work in Immune System? Types of Vaccines Vaccines can be classified into three main groups based on their composition and mode of … Read more
What are Natural Killer (NK) Cells? Definition of NK Cells NK cells, short for Natural Killer cells, are a type of lymphocyte that is part of the innate immune system. They have cytotoxic activity against virus-infected cells and stressed cells like tumor cells. NK cells can recognize and eliminate abnormal cells without the need for … Read more
What are Monoclonal Antibodies? Definition of Monoclonal Antibodies Monoclonal antibodies are artificial antibodies produced in a laboratory by fusing immune cells with cancer cells. They are highly specific in targeting and binding to specific antigens on cells, making them valuable tools in medical research and treatment of diseases, including cancer. Types of monoclonal antibodies based … Read more
What is Complement? Functional categories of Complement Components Complement components can be classified into seven functional categories: 1. Initiator complement components 2. Enzymatic mediators 3. Membrane-binding components or opsonins 4. Inflammatory mediators 5. Membrane attack proteins 6. Complement receptor proteins 7. Regulatory complement components FAQ
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