Differences Between Antigenic Shift and Antigenic Drift

The primary distinction between antigenic drift or antigenic change is the fact that antigenic drift is a way to create change in viruses that is caused by the accumulation of mutations in genes that encode for antigen-binding sites, whereas antigenic shift is a method of combining two kinds of viruses to create one new type that has an assortment of surface antigens of the viruses that were originally.