SouravAugust 20, 2024

A mutant Gα protein with increased GTPase activity would (A) not bind to GTP (B) not bind to GDP (C) show increased signaling (D) show decreased signaling

A mutant Gα protein with increased GTPase activity would
(A) not bind to GTP
(B) not bind to GDP
(C) show increased signaling
(D) show decreased signaling

SouravAugust 20, 2024

Answer

Answer: (D) show decreased signaling
Increased GTPase activity in a Gα protein means it will hydrolyze GTP to GDP more rapidly, leading to decreased signaling because the protein will be in its inactive GDP-bound state more often.

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