Genetics is the branch of biology that studies genes, heredity, and variation in living organisms. It explores how traits are passed from parents to offspring through genes, which are segments of DNA that carry instructions for building and maintaining an organism.
Key areas in genetics include:
What is Enhancer RNA? Enhancer RNAs Detection Functions of enhancer RNAs Biogenesis of Enhancer RNAs 1D eRNAs 2D eRNAs Enhancer RNAs in disease Enhancer RNA and inflammation Enhancer RNA and neurodegenerative disorders Enhancer RNA and cancer Enhancer RNA in diabetes Mechanisms of Enhancer RNAs Transcriptional Noise Transcription-dependent effects Functional activity in cis Functional activity in … Read more
What is Transfer-messenger RNA (tmRNA)? History Properties of tmRNA tmRNA Structure tmRNA contain the following domains; tRNA-Mimic Domain Pseudoknots mRNA-Mimic Domain Protein Partners tmRNA Function ― Trans-Translation Trans-translation of tmRNA activity Steps Regulation of tmRNA activity Facts References
RNA Interference Definition RNA interference is the process by which RNA molecules suppress gene expression by neutralising the targeted messenger RNA molecules. RNA Interference Mechanism The RNA interference mechanism can be explained in the following steps: Why RNAi as a genetic tool? RNA Interference Applications References
What are Ribozymes (RNA enzymes)? Structure and mechanism of Ribozymes Splicing pathways of group I and II introns and the spliceosome Group I Group II Types of Ribozymes There are the different types of ribozymes such as; 1. RNase P ribozyme 2. Hepatitis delta virus (HDV) ribozyme 3. Hammerhead Ribozyme 4. Hairpin Ribozyme 5. Group … Read more
What is tRNA? History of tRNA Properties of tRNA tRNA biogenesis Structure of tRNA The transfer RNA (soluble RNA) molecule has a molecular weight of about 25,000 and has between 71 and 80 nucleotides, most of which are 75. There are at least 20 different kinds of tRNAs, which is the same number of amino … Read more
What is mRNA? This sort of RNA acts by transferring genetic material into ribosomes and transmitting instructions regarding the types of proteins that body cells require. Based on their roles, these RNA types are known as messenger RNA. Therefore, mRNA plays an essential function in the transcription process or during protein synthesis. History of mRNA … Read more
mRNA Degradation in Prokaryotic Cells Bacterial Ribonucleases Bacteria use a vast arsenal of ribonucleolytic enzymes to degrade messenger RNA (mRNA), many of which are exclusive to certain bacterial clades. Endoribonucleases RNase E, RNase Y, and RNase III are the most prominent endonucleases implicated thus far in bacterial mRNA turnover. Exoribonucleases In order to supplement the … Read more
What is Ribosomal RNA (rRNA)? Discovery of Ribosomal RNA Structure of rRNA Detail Structure of rRNA 5S ribosomal RNA 5S ribosomal RNA Structure Location within the ribosome Functions of 5s rRNA 23S ribosomal RNA Structure 23S rRNA Functions 16S ribosomal RNA Structure Functions of 16S ribosomal RNA 28S ribosomal RNA Structure Functions 18S ribosomal RNA … Read more
What is Small Interfering RNA (siRNA)? Properties of siRNA Structure of siRNA Naturally occurring siRNAs have a well-defined structure consisting of phosphorylated 5′ ends, hydroxylated 3′ ends, and two overhanging nucleotides. Mechanism of siRNA action The following describes the process by which natural siRNA induces gene silencing via suppression of translation. siRNA is also similar … Read more
Micro-RNAs (miRNAs) are a family of non-coding RNAs (ncRNAs) that regulate gene expression post-transcriptionally. Since their discovery in 1993, they have been the topic of extensive research due to their role in numerous crucial biological processes. Unlike other noncoding RNAs, microRNAs are created from transcriptional units that are processed by a particular group of endonucleases. … Read more
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