Complement Activation

Biological Consequences of Complement Activation

Biological Consequences of Complement Activation

The Membrane-Attack Complex Can Lyse a Broad Spectrum of Cells Cleavage Products of Complement Components Mediate Inflammation C3b and C4b Binding Facilitates Opsonization The Complement System Also Neutralizes Viral Infectivity The Complement System Clears Immune Complexes from Circulation Complement Deficiencies  C1q, C1r, C1s, C4, and C2 Deficiencies  C3 deficiencies Homozygous deficiencies Congenital deficiencies  The majority … Read more

Classical Pathway of Complement Activation

Classical Pathway of Complement Activation

The classical pathway is a key immune system mechanism that plays an important role in defending the body from foreign invaders. It consists of a series of sequential interactions among complement components that result in the killing of target cells via a process known as cell lysis. The presence of an antibody attached to an antigen, … Read more

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