Describe the principle of the universal genetic code in which different triplets of DNA bases either code for specific amino acids or correspond to start and stop codons

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Describe the differences between leading strand and lagging strand replication as a consequence of DNA polymerase adding nucleotides only in a 5′ to 3′ direction

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Describe the linking of nucleotides by phosphodiester bonds

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Differences in hydrogen bonding between C–G and A–T base pairs

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Describe the importance of complementary base pairing between the 5′ to 3′ strand and the 3′ to 5′ strand (antiparallel strands)

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State that the bases adenine and guanine are purines with a double ring structure, and that the bases cytosine, thymine and uracil are pyrimidines with a single ring structure (structural formulae for bases are not expected)

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Interpret photomicrographs, diagrams and microscope slides of cells in different stages of the mitotic cell cycle and identify the main stages of mitosis

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Outline the role of stem cells in cell replacement and tissue repair by mitosis

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Explain how uncontrolled cell division can result in the formation of a tumour

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Outline the role of telomeres in preventing the loss of genes from the ends of chromosomes during DNA replication

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