What takes RNA primer in DNA replication?

Sourav PanDecember 6, 2024

Answered

In DNA replication, the RNA primer is removed by the enzyme DNA polymerase I (in prokaryotes) or RNase H (in eukaryotes). After the RNA primer has been synthesized by primase to initiate the process of DNA replication, it is eventually removed to allow for the synthesis of DNA. In prokaryotes, DNA polymerase I has both exonuclease activity (to remove the RNA primer) and polymerase activity (to replace the RNA with DNA). In eukaryotes, RNase H first removes the RNA primer, and then DNA polymerase δ fills in the gap with DNA. Afterward, the enzyme DNA ligase seals the remaining nicks between DNA fragments.