State that a gene mutation is a change in the sequence of base pairs in a DNA molecule that may result in an altered polypeptide

• Definition of a Gene Mutation:
  • A gene mutation is a change in the sequence of base pairs within a DNA molecule.
  • This alteration can occur at any time and may be caused by various factors (e.g., environmental, errors during DNA replication).
• Potential Consequence of a Gene Mutation:
  • The change in the DNA sequence may result in an altered polypeptide (protein), which can have significant effects on the organism.
  • The impact of the mutation depends on the type of change, its location, and the gene involved (e.g., synonymous mutations might not alter the protein, while nonsynonymous mutations can lead to different or prematurely terminated proteins).

Key Points from the Web Search Results that Support this Answer:

1. Change in DNA Sequence:
   • “…a change to a gene’s DNA sequence…” (Source: How do genetic mutations lead to genetic variations?)
   • “…a change in one or more nucleotides of DNA” (Source: What Causes a Gene Mutation?)
   • “…changes in the genetic sequence…” (Source: Mutations and diversity among organisms)
2. Potential for Altered Polypeptide:
   • “…they can trigger uncontrolled cell growth, which can encourage diseases like cancer…” (Implying altered protein function) (Source: # What is a gene mutation?)
   • “…nonsynonymous mutation, in which an amino acid sequence is changed. Such mutations lead to either the production of a different protein or the premature termination of a protein.” (Source: Explanation of mutation types)