How to lengthen telomeres?

Lengthening telomeres can be achieved through several mechanisms, most notably by activating or introducing telomerase activity. Since telomerase is responsible for adding repetitive DNA sequences to the ends of chromosomes, enhancing its function can counteract telomere shortening. In experimental settings, telomerase activation has been shown to extend the length of telomeres in cultured cells. However, directly manipulating telomerase in humans presents challenges and potential risks, including an increased risk of cancer due to the promotion of uncontrolled cell proliferation. Other methods that have been proposed or investigated for telomere lengthening include lifestyle changes, such as increased physical activity, stress reduction, and dietary modifications, though these factors have not been conclusively proven to lengthen telomeres in a sustainable way. Certain compounds, such as those found in antioxidants and some plant-based supplements, are also being studied for their potential to promote telomere health and slow telomere shortening. However, more research is required to determine effective and safe approaches to telomere lengthening.