How to derive the Henderson-Hasselbalch equation?

Sourav PanApril 24, 2025

Answered

– Start with the expression for the acid dissociation constant: Ka = [H⁺][A⁻]/[HA] – Solve for [H⁺]: [H⁺] = Ka × [HA]/[A⁻] – Take the negative logarithm of both sides: -log₁₀[H⁺] = -log₁₀Ka – log₁₀([HA]/[A⁻]) – Recognize that -log₁₀[H⁺] = pH and -log₁₀Ka = pKa: pH = pKa + log₁₀([A⁻]/[HA])

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