How to calculate pKa using the Henderson-Hasselbalch equation?

Sourav PanApril 24, 2025

Answered

– Rearrange the equation to solve for pKa: pKa = pH – log₁₀([A⁻]/[HA]) – Determine the pH of the solution and the concentrations of [A⁻] and [HA]. – Calculate the ratio [A⁻]/[HA] and its logarithm. – Subtract this value from the pH to find the pKa.

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