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Sourav PanApril 18, 2025

How much ATP does the Krebs cycle produce?

How much ATP does the Krebs cycle produce?

Sourav Pan
Sourav PanApril 18, 2025

Answered

In one complete turn of the Krebs cycle, 1 molecule of GTP (or ATP) is produced directly through substrate-level phosphorylation. Additionally, the cycle generates 3 NADH and 1 FADH₂, which subsequently donate electrons to the electron transport chain, indirectly producing ATP. 3 NADH yield about 7.5 ATP (3 × 2.5 ATP) and 1 FADH₂ yields about 1.5 ATP. Combined, this results in approximately 10 ATP equivalents per cycle turn. Since two acetyl-CoA molecules are produced from one glucose, total ATP production per glucose via the Krebs cycle is about 20 ATP equivalents.

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