When does glycogenolysis peak on the USMLE?

On the USMLE (United States Medical Licensing Examination), glycogenolysis is likely to be tested in relation to conditions of fasting, exercise, or low blood glucose levels. Glycogenolysis typically peaks during fasting states or in response to exercise when energy demand increases. It is also activated when blood glucose levels fall, especially during prolonged fasting or between meals. Understanding the hormonal regulation of glycogenolysis (e.g., the roles of glucagon and epinephrine) is important for the USMLE.