What are the structural differences among LDH isoforms, and how do they affect their function?

Sourav PanDecember 14, 2024

Answered

Lactate dehydrogenase (LDH) consists of five distinct isoforms that differ in the ratio of H (heart) and M (muscle) subunits present in their tetrameric structure. LDHA predominantly favors lactate production and is not inhibited by high concentrations of pyruvate, while LDHB favors pyruvate production. These structural differences influence their enzymatic activity and functional roles in various tissues.

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