How might understanding of dominant and recessive alleles influence decisions on embryo screening?

Question

Sourav · Answer

Here are several ways this knowledge influences such decisions:

1. Identification of Genetic Risks

Dominant Alleles: If a genetic disorder is caused by a dominant allele, only one copy of the mutated gene is needed for the disorder to manifest. In families with a history of dominant disorders, embryo screening can help identify embryos carrying the dominant allele, allowing parents to select embryos that do not carry the mutation.
Recessive Alleles: For recessive disorders, both parents must carry a mutated allele for their child to be affected. Screening can identify carrier status in parents and assess the risk of passing on the disorder. If both parents are carriers, embryo screening can help select embryos that do not inherit two copies of the recessive allele, significantly reducing the risk of the child being affected.

Targeted Testing: In cases where specific genetic disorders are known to run in families (such as Huntington's disease or cystic fibrosis), understanding whether these conditions are dominant or recessive guides the choice of embryos during PGT. For dominant disorders, embryos with the mutated gene can be excluded from selection.
Comprehensive Screening: Advances in techniques such as whole-genome sequencing allow for broader screening beyond known disorders. This enables parents to assess multiple genetic risks simultaneously, including both dominant and recessive alleles, providing a more comprehensive picture of potential inherited conditions.

Genetic Counseling: Knowledge of dominant and recessive inheritance patterns informs genetic counseling sessions for prospective parents considering embryo screening. Counselors can explain the implications of being carriers for recessive disorders or having a family history of dominant disorders, helping couples understand their options.
Informed Consent: Understanding these genetic principles ensures that parents can make informed decisions about embryo selection based on their specific genetic backgrounds and risks.

Selection Criteria: The decision to screen embryos based on whether alleles are dominant or recessive raises ethical questions about which traits are deemed undesirable. Parents may face moral dilemmas about selecting against certain conditions, particularly if those conditions do not severely impact quality of life.
Social Implications: The ability to select against certain genetic traits could influence societal views on disability and health, potentially leading to stigmatization or discrimination against individuals with certain inherited conditions.

Long-term Outcomes: Understanding how alleles are inherited helps predict the likelihood of future generations inheriting specific traits or conditions. This knowledge can guide family planning decisions and influence reproductive choices over time.