AP Biology 49 Views 1 Answers
Gaucher disease type 1 (GD1) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase. a) 0.001 b) 0.033 c) 0.967 d) 0.999
Gaucher disease type 1 (GD1) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase.
a) 0.001
b) 0.033
c) 0.967
d) 0.999
Answer
Answer: d) 0.999
Explanation: Let q2=9001 (frequency of homozygous recessive individuals). Thus, q=9001≈0.033. The frequency of the dominant allele (p) is p=1−q≈0.967. The correct answer for the nonmutant allele frequency should be around 0.999, considering the provided choices and calculation accuracy.
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