Questions and Answers

Determine the correctness or otherwise of the following Assertion (a) and the Reason (r):
Assertion: The elucidation of ribosome structure helps in the development of new generation drugs.
Reason: The high resolution of macromolecular structure has enabled in structure-based drug design.
Options:
(A) both (a) and (r) are true and (r) is the correct reason for (a)
(B) both (a) and (r) are true but (r) is not the correct reason for (a)
(C) (a) is true but (r) is false
(D) (a) is false but (r) is true

Match items in Group I with Group II:
Group I
P. Alzheimer’s disease
Q. Mad cow disease
R. Sickle cell anaemia
S. Swine flu
Group II
1. H1N1
2. Hemoglobin
3. Prions
4. Amyloid
Options:
(A) P-4, Q-3, R-2, S-1
(B) P-3, Q-4, R-1, S-2
(C) P-2, Q-1, R-4, S-3
(D) P-1, Q-2, R-3, S-4

Match items in Group I with Group II:
Group I
P. Glycolytic pathway
Q. Eukaryotic oxidative metabolism
R. Glyoxylate cycle
S. Calvin cycle
Group II
1. Chloroplast
2. Glyoxysomes
3. Mitochondria
4. Cytosol
Options:
(A) P-1, Q-2, R-3, S-4
(B) P-2, Q-3, R-4, S-1
(C) P-4, Q-3, R-2, S-1
(D) P-3, Q-4, R-1, S-2

Structured William’s model:
P. can describe the changes in intracellular components of the cell during growth
Q. can not describe the death phase of the cells
R. can describe the variation of size of cells in the different phases of growth
S. can not describe the lag period of growth
Options:
(A) P, Q and S only
(B) P, Q and R only
(C) Q, R and S only
(D) P, R and S only

In a well-aerated and agitated microbial culture, the ‘supply’ of oxygen is equal to demand:
C = instantaneous value of dissolved oxygen concentration
T = specific oxygen uptake rate per unit weight of cells
X = dry weight of the cells per unit volume
Options:
(A) (r X) / (C*- C)
(B) (r) / X (C*- C)
(C) (C”- C) / (r X)
(D) (X) / r (C*- C)

Determine the correctness of the following statements:
I. Enhancer sequences are those DNA sequences that are involved in increasing the rate of DNA replication.
II. Enhancer sequences work by binding with eukaryotic gene activator factors.
Options:
(A) only I is true
(B) only II is true
(C) both I and II are true
(D) both I and II are false

Determine the correctness or otherwise of the following Assertion (a) and the Reason (r):
Assertion: N-methyl-N’-nitro-N-nitrosoguanidine (NTG) is an effective chemical mutagen.
Reason: Mutations induced by NTG mainly are GC → AT transitions.
Options:
(A) both (a) and (r) are true and (r) is the correct reason for (a)
(B) both (a) and (r) are true but (r) is not the correct reason for (a)
(C) (a) is true but (r) is false
(D) (a) is false but (r) is true

Determine the correctness or otherwise of the following Assertion (a) and the Reason (r):
Assertion: IgM is found in serum as a pentameric protein consisting of five IgM monomers.
Reason: The pentameric form of IgM is due to cross-linking of IgM monomers via peptide bond.
Options:
(A) both (a) and (r) are true and (r) is the correct reason for (a)
(B) both (a) and (r) are true but (r) is not the correct reason for (a)
(C) (a) is true but (r) is false
(D) (a) is false but (r) is true

Match the products in Group I with their respective organisms in Group II:
Group I
P. Glycerol
Q. Glutamic acid
R. Curdlan
S. Amphotericin B
Group II
1. Corynebacterium glutamicum
2. Alcaligenes faecalis
3. Dunaliella salina
4. Streptomyces nodosus
Options:
(A) P-2, Q-1, R-3, S-4
(B) P-4, Q-2, R-1, S-3
(C) P-3, Q-1, R-2, S-4
(D) P-2, Q-1, R-4, S-3

Match the items in Group I with Group II:
Group I
P. Circular dichroism
Q. X-ray crystallography
R. Freeze-drying
S. Ultracentrifugation
Group II
1. Concentration
2. Sedimentation coefficient
3. Secondary structure determination
4. Tertiary structure determination
Options:
(A) P-4, Q-1, R-2, S-3
(B) P-1, Q-4, R-3, S-2
(C) P-2, Q-3, R-4, S-1
(D) P-3, Q-4, R-1, S-2