Describe the effects of excessive consumption of alcohol: reduced self-control, depressant, effect on reaction times, damage to liver and social implications

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Explain that the cholera bacterium produces a toxin that causes secretion of chloride ions into the small intestine, causing osmotic movement of water into the gut, resulting in diarrhoea, dehydration and loss of ions from the blood

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Explain the importance of a clean water supply, hygienic food preparation, good personal hygiene, waste disposal and sewage treatment in controlling the spread of cholera (details of the stages of sewage treatment are not required)

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Describe the role of the mosquito as a vector of disease

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Describe that a pathogen may be transmitted: (a) through direct contact, including through blood or other body fluids (b) indirectly, including from contaminated surfaces or food, from animals, or from the air

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Describe a pathogen as a disease-causing organism

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List the components of blood as red blood cells, white blood cells, platelets and plasma

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Describe the transfer of substances between blood in capillaries, tissue fluid and body cells

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State the functions of the components of blood: (a) red blood cells – oxygen transport (b) white blood cells – antibody production by lymphocytes and engulfing pathogens by phagocytes (c) platelets – clotting by converting soluble fibrinogen to insoluble fibrin to prevent blood loss and the entry of pathogens (d) plasma – transport, limited to: blood cells, ions, glucose, amino acids, hormones, carbon dioxide, urea, vitamins and plasma proteins

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Explain how the structure of arteries, veins and capillaries is related to the pressure of the blood that they transport

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