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Use the t-test to compare the means of two different samples (the formula for the t-test will be provided, as shown in the Mathematical requirements)
Explain the genetic basis of discontinuous variation and continuous variation
Explain what is meant by discontinuous variation and continuous variation
Explain, with examples, that phenotypic variation is due to genetic factors or environmental factors or a combination of genetic and environmental factors
Explain how gibberellin activates genes by causing the breakdown of DELLA protein repressors, which normally inhibit factors that promote transcription
State that transcription factors are proteins that bind to DNA and are involved in the control of gene expression in eukaryotes by decreasing or increasing the rate of transcription
Explain genetic control of protein production in a prokaryote using the lac operon (knowledge of the role of cAMP is not expected)
Describe the differences between structural genes and regulatory genes and the differences between repressible enzymes and inducible enzymes
Explain the role of gibberellin in stem elongation including the role of the dominant allele, Le, that codes for a functional enzyme in the gibberellin synthesis pathway, and the recessive allele, le, that codes for a non-functional enzyme
Explain the relationship between genes, proteins and phenotype with respect to the: • TYR gene, tyrosinase and albinism • HBB gene, haemoglobin and sickle cell anaemia • F8 gene, factor VIII and haemophilia • HTT gene, huntingtin and Huntington’s disease
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