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The Krebs cycle, also known as the citric acid cycle or tricarboxylic acid (TCA) cycle, is a crucial metabolic pathway involved in aerobic respiration. It oxidizes acetyl-CoA to produce CO₂, NADH, FADH₂, and GTP (or ATP), which are critical for energy production and biosynthesis. Discovered by Sir Hans Adolf Krebs in 1937, it operates in the mitochondrial matrix of eukaryotic cells and the cytoplasm of prokaryotic cells. Besides energy generation, it provides intermediates for multiple anabolic processes, including amino acid, nucleotide, and heme synthesis.
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