What is total lesion glycolysis?

Total lesion glycolysis refers to the overall process of glycolysis in a tissue or cell, particularly in the context of abnormal or diseased tissues, such as cancer. In tumors, glycolysis can be upregulated, a phenomenon known as the Warburg effect, where cells rely on anaerobic glycolysis for energy production, even in the presence of oxygen. This can be indicative of the metabolic state of the tissue.