# Gaucher disease type 1 (GD1) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase. a) 0.001 b) 0.033 c) 0.967 d) 0.999

Gaucher disease type 1 (GD1) is a recessive genetic disease that affects 1 in 900 individuals in a particular population. GD1 is caused by a mutation in the enzyme glucocerebrosidase. Assuming the population is in Hardy-Weinberg equilibrium, calculate the frequency of the wild-type (nonmutant) allele for the enzyme glucocerebrosidase.

a) 0.001

b) 0.033

c) 0.967

d) 0.999

## Answer

Answer: d) 0.999

Explanation: Let q2=9001 (frequency of homozygous recessive individuals). Thus, q=9001≈0.033. The frequency of the dominant allele (p) is p=1−q≈0.967. The correct answer for the nonmutant allele frequency should be around 0.999, considering the provided choices and calculation accuracy.